Frequently Asked Questions

Frequently Asked Questions

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What is EVOTAZ?

EVOTAZ is a prescription medicine used with other antiretroviral medicines to treat HIV-1 (Human Immunodeficiency Virus) infection in adults. EVOTAZ contains the prescription medicines REYATAZ® (atazanavir) and Tybost® (cobicistat).

It is not known if EVOTAZ is safe and effective in children under 18 years of age.

EVOTAZ does not cure HIV infection or AIDS (Acquired Immunodeficiency Syndrome). You must keep taking HIV medicines to control HIV infection and decrease HIV-related illnesses.

When used with other antiretroviral medicines to treat HIV-1 infection, EVOTAZ may help:

  • Reduce the amount of HIV-1 in your blood. This is called “viral load”
  • Increase the number of CD4+ T cells in your blood that help to fight off other infections
How does EVOTAZ work?

EVOTAZ helps prevent cells infected by HIV from producing more HIV. This reduces the amount of the virus in your body. EVOTAZ is one of several treatment options your doctor may consider. EVOTAZ does not cure HIV infection or AIDS. You must stay on continuous HIV therapy to help control HIV infection and reduce the chance of HIV-related illnesses.

HIV is a virus that multiplies quickly. Untreated, it can make billions of copies of itself every day. But HIV cannot multiply on its own. It uses the CD4+ cells of your immune system. Normally, CD4+ cells fight bacteria and viruses to keep you healthy. As HIV multiplies, it wipes out CD4+ cells.

EVOTAZ is in the class of HIV drugs known as protease inhibitors (PIs). PIs prevent HIV from copying itself effectively. EVOTAZ should be used as part of an HIV regimen.

EVOTAZ may help raise your CD4+ cell count and lower your viral load to undetectable.

Who should not take EVOTAZ?

Do not take EVOTAZ (atazanavir and cobicistat) if you:

  • Are allergic to any of the ingredients in EVOTAZ
  • Are taking these drugs because taking them with EVOTAZ may cause serious, life threatening side effects: alfuzosin (Uroxatral®), carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®), cisapride (Propulsid®, Propulsid® Quicksolv®), colchicine (Mitigare®, Colcrys®) if you have liver or kidney problems, dronedarone hydrochloride (Multaq®), ergot containing medicines (D.H.E. 45®, Embolex®, Migranal®, Cafergot®, Migergot®, Ergomar®, Ergostat®, Medihaler®, Wigraine®, Wigrettes®, Methergine®), indinavir (Crixivan®), irinotecan (Camptosar®), lovastatin (Advicor®, Altoprev®, Mevacor®), lurasidone (Latuda®), oral midazolam (Versed®), phenobarbital (Luminal®), phenytoin (Dilantin®, Phenytek®), nevirapine (Viramune®, Viramune XR®), pimozide (Orap®), ranolazine (Ranexa®), rifampin (Rimactane®, Rifadin®, Rifater®, Rifamate®), sildenafil (Revatio®) when used for lung problems, simvastatin (Zocor®, Vytorin®, Simcor®), triazolam (Halcion®) or products that contain St. John's wort (Hypericum perforatum)
Does EVOTAZ cure HIV infection or AIDS?

EVOTAZ does not cure HIV infection or AIDS (Acquired Immunodeficiency Syndrome). You must keep taking HIV drugs to control HIV infection and decrease HIV-related illnesses.

Does EVOTAZ reduce the risk of passing HIV to others?

No. EVOTAZ does not lower your chance of passing HIV to other people through sexual contact, sharing needles, or being exposed to your blood. To reduce the risks linked to sexual contact, you should get tested for sexually transmitted diseases (STDs). Let your partner know your HIV and STD status.

For your health and the health of others, it is important to always practice safer sex by using a latex or polyurethane condom or other barrier to lower the chance of sexual contact with semen, vaginal secretions, or blood.

Never share or reuse piercing, tattooing, or injection needles. If you are an injection drug user, consider seeking treatment for substance use.

Can I take EVOTAZ if I've never taken an anti-HIV medication?

Yes. EVOTAZ in HIV combination therapy can be taken by adults who are starting HIV treatment for the first time.

Once-daily EVOTAZ in combination therapy has been shown to be effective in helping to manage HIV. It can help lower your viral load to undetectable and may raise your CD4+ cell count. EVOTAZ does not cure HIV infection or AIDS. You must stay on continuous HIV therapy to control HIV infection and decrease HIV-related illnesses.

Can I change to EVOTAZ if I am currently on a different HIV medication?

Doctors may change your HIV therapy for a variety of reasons. EVOTAZ as part of combination therapy is one of several treatment options your doctor may consider.

What should I tell my healthcare provider before I take EVOTAZ?

Before you take EVOTAZ, tell your healthcare provider:
If you are pregnant or plan to become pregnant. It is not known if EVOTAZ will harm your unborn baby. Pregnant women have developed a serious condition called lactic acidosis (a buildup of lactic acid in the blood) when taking EVOTAZ with other HIV drugs called nucleoside analogues.

  • Hormonal forms of birth control, such as shots, vaginal rings or implants, contraceptive patch, and some birth control pills, may not work when you are taking EVOTAZ. Talk to your healthcare provider about forms of birth control that may be used during treatment with EVOTAZ
  • Pregnancy Registry. There is a pregnancy registry for women who take antiviral drugs during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry
  • After your baby is born, tell your healthcare provider if your baby's skin or the white part of his/her eyes turns yellow

If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are taking EVOTAZ. You should not breastfeed if you have HIV because of the risk of passing HIV to your baby. It is not known if EVOTAZ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby.

If you have heart, liver, or gallbladder problems or are infected with the hepatitis B or C virus. Learn what else to discuss with your doctor

If you have end-stage kidney disease managed with hemodialysis. Learn what else to discuss with your doctor

If you have diabetes. Learn what else to discuss with your doctor

If you have hemophilia. Learn what else to discuss with your doctor

About all the drugs you take, including prescription and over-the-counter drugs, vitamins, and herbal supplements. Keep a list of your drugs with you to show your healthcare provider. Some drugs can cause serious side effects if taken with EVOTAZ. Learn more about possible drug interactions with EVOTAZ

Which drugs should I avoid while taking EVOTAZ?

Do not take EVOTAZ if you

  • Are allergic to any of the ingredients in EVOTAZ
  • Are taking any of these drugs. EVOTAZ may cause serious life-threatening side effects or death when used with these drugs:
    • alfuzosin (Uroxatral®)
    • carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
    • cisapride (Propulsid®, Propulsid® Quicksolv®)
    • colchicine (Colcrys®, Mitigare®) if you have liver or kidney problems
    • dronedarone hydrochloride (Multaq®)
    • ergot-containing medicines:
      • dihydroergotamine mesylate (D.H.E. 45®, Embolex®, Migranal®)
      • ergotamine tartrate (Cafergot®, Migergot®, Ergomar®, Ergostat®, Medihaler® Wigraine®, Wigrettes®)
      • methylergonovine (Methergine®)
    • indinavir (Crixivan®)
    • irinotecan (Camptosar®)
    • lovastatin (Advicor®, Altoprev®, Mevacor®)
    • lurasidone (Latuda®)
    • midazolam (Versed®), when taken by mouth for sedation
    • nevirapine (Viramune®, Viramune XR®)
    • phenobarbital (Luminal®)
    • phenytoin (Dilantin®, Phenytek®)
    • pimozide (Orap®)
    • ranolazine (Ranexa®)
    • rifampin (Rimactane®, Rifadin®, Rifater®, Rifamate®)
    • sildenafil (Revatio®), when used for the treatment of pulmonary arterial hypertension (PAH)
    • simvastatin (Zocor®, Vytorin®, Simcor®)
    • St. John’s wort (Hypericum perforatum), or a product that contains St. John’s wort
    • triazolam (Halcion®)

The above list of drugs is not complete. Please refer to Patient Information for a list of drugs that may call for your therapy to be watched more closely or may call for a change in dose or dose schedule of EVOTAZ or the other drug. Know the drugs you take. Keep a list of your drugs and show it to your healthcare provider and pharmacist when you get a new drug.

Remember:

  1. Know all the drugs you take.
  2. Tell your healthcare provider about all the drugs you take.
  3. Do not start a new drug without talking to your healthcare provider.
    When you get a new drug, show it to your healthcare provider and your pharmacist.
How do I take EVOTAZ?

Take EVOTAZ once every day exactly as told by your healthcare provider. Your healthcare provider will prescribe the amount of EVOTAZ that is right for you.

Do not change your dose or stop taking EVOTAZ without talking to your healthcare provider.

  • Stay under the care of your healthcare provider during treatment with EVOTAZ
  • EVOTAZ must be used with other antiretroviral drugs
  • Take EVOTAZ 1 time each day with food
  • If you miss a dose of EVOTAZ, take the dose as soon as possible and then return to your normal schedule.
  • If a dose of EVOTAZ is missed, do not double the next dose
  • If you take too much EVOTAZ, call your healthcare provider or go to the nearest hospital emergency room right away
  • When your supply of EVOTAZ starts to run low, get more from your healthcare provider or pharmacy. It is important not to run out of EVOTAZ. The amount of HIV-1 in your blood may increase if the drug is stopped for even a short time. The virus may become resistant to EVOTAZ and harder to treat
Can I take EVOTAZ if I am pregnant?

It is not known if EVOTAZ will harm your unborn baby. Pregnant women have developed a serious condition called lactic acidosis (a buildup of lactic acid in the blood) when taking EVOTAZ with other HIV medicines called nucleoside analogues. You and your healthcare provider will need to decide if EVOTAZ is right for you. If you use EVOTAZ while you are pregnant, talk to your healthcare provider about the antiretroviral pregnancy registry. And after your baby is born, tell your healthcare provider if your baby's skin or the white part of his/her eyes turns yellow.

Can I take EVOTAZ if I am breastfeeding?

Do not breastfeed. It is not known if EVOTAZ can be passed to your baby in your breast milk and whether it could harm your baby. Also, mothers with HIV-1 should not breastfeed because HIV-1 can be passed to the baby in the breast milk.

Can HIV become resistant to EVOTAZ?

Over time, HIV can become resistant to HIV drugs. When patients develop drug resistance to a drug in a certain class (such as EVOTAZ, which is a protease inhibitor [PI]), they often become resistant to many or all of the drugs in that class.

Learn more about how EVOTAZ works

How should I store EVOTAZ?

Do not store this drug in a damp place.

  • Store EVOTAZ tablets at room temperature between 68°F and 77°F (20°C and 25°C)
  • Keep tablets in a tightly closed container
  • Keep EVOTAZ and all drugs out of the reach of children
What are the ingredients in EVOTAZ?

Active Ingredients: atazanavir and cobicistat
Inactive Ingredients: croscarmellose sodium, crospovidone, hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, silicon dioxide, sodium starch glycolate, and stearic acid. The film-coating contains hypromellose, red iron oxide, talc, titanium dioxide, and triacetin.

Tell your healthcare provider if you think you have had an allergic reaction to any of these ingredients.

How can I get help paying for EVOTAZ?
Not an actual patient
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More Important Safety Information

SELECTED IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

Who should not take EVOTAZ (atazanavir and cobicistat)?

Do not take EVOTAZ if you:

  • Are allergic to any of the ingredients in EVOTAZ
  • Are taking the following medicines because taking them with EVOTAZ may cause serious, life-threatening side effects: alfuzosin (Uroxatral®), carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®), cisapride (Propulsid®, Propulsid® Quicksolv®), colchicine (Mitigare®, Colcrys®) if you have liver or kidney problems, dronedarone hydrochloride (Multaq®), ergot containing medicines (D.H.E. 45®, Embolex®, Migranal®, Cafergot®, Migergot®, Ergomar®, Ergostat®, Medihaler®, Wigraine®, Wigrettes®, Methergine®), indinavir (Crixivan®), irinotecan (Camptosar®), lovastatin (Advicor®, Altoprev®, Mevacor®), lurasidone (Latuda®), oral midazolam (Versed®), nevirapine (Viramune®, Viramune XR®), phenobarbital (Luminal®), phenytoin (Dilantin®, Phenytek®), pimozide (Orap®), ranolazine (Ranexa®), rifampin (Rimactane®, Rifadin®, Rifater®, Rifamate®), sildenafil (Revatio®) when used for lung problems, simvastatin (Zocor®, Vytorin®, Simcor®), triazolam (Halcion®) or products that contain St. John’s wort (Hypericum perforatum)

What should I tell my healthcare provider before taking EVOTAZ?

  • If you have heart problems, liver problems, including hepatitis B or C virus infection, kidney problems, diabetes, or hemophilia or any other medical condition
  • If you are pregnant or plan to become pregnant. It is not known if EVOTAZ will harm your unborn baby. Pregnant women have developed a serious condition called lactic acidosis (a buildup of lactic acid in the blood)
  • If you take hormonal forms of birth control, such as injections, rings, implants, contraceptive patches or birth control pills, as some of these may not work when you are taking EVOTAZ
  • After your baby is born, tell your healthcare provider if your baby’s skin or the white part of his/her eyes turns yellow
  • If you are breastfeeding (nursing) or plan to breastfeed. Do not breastfeed if you have HIV or if you take EVOTAZ. HIV can be passed to the baby in breast milk. It is not known if EVOTAZ passes into breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines interact with EVOTAZ. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking any new medicines without first talking to your healthcare provider.

What are the possible side effects of EVOTAZ?

EVOTAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:

  • A change in the way your heart beats (heart rhythm change). You may feel dizzy or lightheaded, as these could be symptoms of a heart problem
  • Skin rash is common with EVOTAZ, and can sometimes be severe. Skin rash usually goes away within 2 weeks. Severe rash may develop with other symptoms which can be serious. If you develop a severe rash with any of the following symptoms, call your healthcare provider or go to the nearest hospital emergency room right away: general feeling of discomfort (“flu like” symptoms); fever; muscle or joint aches; red or inflamed eyes; blisters; mouth sores; swelling of your face; painful, warm, or red lump under your skin
  • Kidney problems can occur when EVOTAZ is taken with certain other medicines, as this can cause new or worse kidney problems, including kidney failure. Kidney stones have happened in some people who take atazanavir, one of the medicines in EVOTAZ. Symptoms may include pain in your low back or low stomach area, blood in your urine, pain when you urinate
  • Gallbladder problems have happened in some people who take atazanavir, one of the medicines in EVOTAZ. Symptoms may include pain in the right or middle upper stomach area, fever, nausea and vomiting, and your skin or the white part of your eyes turns yellow
  • Liver problems, including hepatitis B or C, may get worse when taking EVOTAZ. Your healthcare provider will do blood tests before and during treatment with EVOTAZ. Symptoms of liver problems may include: your skin or the white part of your eyes turns yellow, dark (tea colored) urine, light colored stools, nausea, itching, or stomach-area pain
  • Yellowing of the skin or the white part of your eyes. This may occur due to increases in bilirubin levels in the blood
  • Changes in your immune system (Immune Reconstitution Syndrome). Tell your healthcare provider if you start having new symptoms after starting EVOTAZ
  • Diabetes and high blood sugar can happen or get worse in some people who take protease inhibitor medicines like EVOTAZ. Some people may need to start diabetes medicine or change their diabetes medicine
  • Changes in body fat can happen in people taking HIV medicines. The exact cause and long-term health effects are not known
  • Increased bleeding problems in people with hemophilia have happened when taking protease inhibitors including EVOTAZ

The most common side effects of EVOTAZ are yellowing of the skin and rash.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Please see U.S. Full Prescribing Information and Patient Information

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.